Pathway-wide base editing charts chemical-genetic interactions in MAPK signaling
CRISPR base editor (BE) scanning enables sequence-level interrogation of proteins at scale in their native cellular and genomic contexts. This approach opens new opportunities to dissect cellular pathways, where signaling depends on coordinated interactions among multiple pathway proteins. We apply BE scanning to the R...
James Woods, C. X. Hu, Dong-Man Jang et al.
· bioRxiv · 0 citations