Author

Hyun-Wook Cho

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Open access Sep 2026

Cooperative mechanisms of β-ketoacyl-ACP synthase III and acyl carrier protein in branched-chain fatty acid biosynthesis in Cutibacterium acnes.

The branched-chain fatty acids (BCFAs) synthesized by Cutibacterium acnes contribute to its membrane fluidity and adaptation to anaerobic environments. We investigated the structural and functional characteristics of β-ketoacyl-ACP synthase III (CaKAS III) and its cofactor, acyl carrier protein (CaACP) that are key com...

Yoojin Oh, Hyun-Wook Cho, Woo Cheol Lee et al. · Biochemical and Biophysical... · 0 citations

#protein folding Open access Sep 2026

From stability to specificity: mechanistic insights into the functions of two acyl carrier proteins, ApeE and ApeF, in aryl polyene biosynthesis in A. baumannii

Comparative analysis reveals that ApeE exhibits greater conformational plasticity, enabling it to accommodate bulky APE intermediates, reflecting its role in flexible substrate handling, while ApeE’s flexibility facilitates substrate switching necessary for APE biosynthesis.

Hyun-Wook Cho, C. Lee, Yangmee Kim · Journal of Analytical Scienc... · 0 citations