The mechanisms underlying seasonal mood variation are incompletely characterised. We tested whether wearable-measured sleep, activity, circadian and light exposure patterns are associated with seasonal mood variation in young Australians with emerging mood disorders. We analysed 733 observation periods from 422 partici...
M. Shin, E. Tonini, J. Carpenter et al.· Journal of Biological Rhythm...· 0 citations
Findings support the face validity and potential clinical utility of a circadian subtype of depression as a clinical profile and support the face validity and potential clinical utility of its biology and predictive utility.
E. Tonini, J. Crouse, M. Shin et al.· The British journal of psych...· 1 citation
Background Mental disorders are a leading cause of disease burden in 10–24-year-olds. In Australia, fragmentation within and across health, mental health and human services sectors contributes to gaps in service provision and increased disease burden. Comprehensive methodologies are needed to identify service gaps and...
A. Watson, J. Menssink, K. Filia et al.· BJPsych Open· 1 citation
CRD-load was associated with clinical symptoms, functional impairment, and mood-related genetic liability, and these findings support further evaluation of brief assessments of circadian-associated phenotypes for identifying young people at greater clinical burden and informing circadian-focused prevention and early in...
M. Shin, E. Tonini, J. Carpenter et al.· medRxiv· 0 citations
Accurate and precise quantification of trace-level cytokines in complex biological matrices remains challenging, limiting their use as longitudinal biomarkers in clinical studies. Here, we present a nanotechnology-enabled surface-enhanced Raman scattering (SERS) platform incorporating an internal standard (IS) for di...
Yi-Wen Zhang, Fahimeh Farokhinejad, Jacob J. Crouse et al.· Analytical Chemistry· 0 citations
There are likely causal effects of adolescent chronotype on mental health symptoms, but these are dependent on the dimension of mental health and period of adolescence.
R. Visontay, H. Byrne, E. Devine et al.· Journal of Child Psychology...· 0 citations
Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk o...
E. Byrne, Nathan A. Gillespie, J. Najman et al.· Molecular Psychiatry· 0 citations
Together, these results implicate a constellation of rare variants that map onto neuronal biology and demonstrate that diverse global populations converge on shared genetic signals underlying BD risk.
Calwing Liao, Robert Ye, J. Sealock et al.· medRxiv· 0 citations
ABSTRACT Background While growing evidence implicates sleep‐wake and circadian rhythm disturbances (SCRDs) in the onset and course of mood and psychotic disorders, longitudinal studies using objective measures are limited. This clinical cohort study examined whether actigraphy‐derived SCRDs (sleep duration, timing, and...
J. Carpenter, J. Crouse, M. Varidel et al.· Bipolar Disorders· 0 citations
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al.· Research Square· 0 citations
Sleep quality and affective symptoms exhibit a feedback loop, whereby poor sleep quality influences affective symptoms over consecutive days, which supports interventions that target sustained improvement in sleep and possibly circadian regulation to improve affective symptoms.
M. Varidel, L. Borgnolo, V. An et al.· medRxiv· 0 citations
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