Imran Ullah

AAV9 Gene Therapy for Ovarian Dysfunction and Reproductive Aging: Molecular Mechanisms, Therapeutic Targets, and Translational Perspectives

Female infertility is a growing concern in developed countries as delayed childbearing and ovarian dysfunction become more common. Ovarian decline is characterized by follicular depletion, granulosa cell dysfunction, aneuploidy, spindle assembly defects, mitochondrial damage, DNA damage, telomere shortening, stromal re...

Genetic and Clinical Spectrum of Inborn Errors of Immunity in the Pakistani Population: A Systematic Review

Inborn errors of immunity (IEIs), historically termed primary immunodeficiencies (PID), are a broad group of rare inherited diseases caused by genetic variants that impair the development or functioning of the immune system. Although IEIs are genetically determined, molecular diagnoses remain unavailable for a su...

Carboxymethyl cellulose stabilized copper nanocomposite CMC@Cu0 for the catalytic degradation of Congo red and crystal violet dyes

Genetic background determines allele-specific Pfkelch13-mediated artemisinin tolerance and persistence in Plasmodium falciparum

Artemisinin-based combination therapies are the frontline treatment for Plasmodium falciparum malaria, but their efficacy is threatened by Artemisinin partial resistance (ARTR). ARTR in Plasmodium falciparum is mediated by Pfkelch13 (k13) mutations but remains rare in West Africa. A critical question is whether short-t...

Juglone Attenuates CCl₄‐Induced Hepatic Injury in Mice With Associated Modulation of Oxidative Stress and Inflammasome‐Related mRNA Expression

Results are best interpreted as gene‐level associations compatible with modulation of oxidative stress, inflammasome‐ and pyroptosis‐related mRNA expression, ER stress responses, apoptosis‐linked transcripts, and remodeling‐associated transcripts, rather than as confirmed pathway inhibition or established antifibrotic...