Open access
Jul 2026
Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system
The cryo-electron microscopy structure of the full-length human VPS4B hexamer in six-membered helical “spiral staircase” states suggests a mechanism for substrate-dependent hexamerization and priming of VPS4 for its ESCRT-III remodeling activity.
James H. Hurley, Yu-Chao Zhang, Shuixia Tan et al.
· Research Square · 0 citations