Principles of NMDA receptor co-agonism at cortical fast-spiking GABAergic interneurons in the adolescent prefrontal cortex
It is discovered that d-serine but not glycine is critical for maintaining the activity of NMDARs at FS-PV+ interneurons in the prelimbic area of the prefrontal cortex and that loss of its functions would recapitulate the synaptic deficits observed in several neuropsychiatric diseases like schizophrenia.