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Review Open access Sep 2026

AGA Clinical Practice Update on the Evaluation and Management of Metabolic Dysfunction- and Alcohol-Associated Liver Disease: Expert Review.

DESCRIPTION Steatotic liver disease (SLD) is the leading cause of chronic liver disease and liver-related mortality in the United States. The 2023 multisociety consensus nomenclature was intended to develop a more evidence-based framework regarding the differing forms of SLD, including metabolic dysfunction-associated...

J. Arab, H. Malhi, G. S. Winder et al. · 0 citations
Open access Sep 2026

Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease.

Lean MASLD represents a distinct phenotype with milder histologic disease but similar clinical outcomes compared with overweight/obese MASLD, and the FIB-4 demonstrated lower accuracy for predicting advanced fibrosis in lean vs overweight/obese MASLD.

L. de Avila, K. Al-Naamani, M. Papatheodoridi et al. · 1 citation
Review Oct 2026

Alcohol-associated liver disease.

Alcohol-associated liver disease (ALD) is the leading cause of liver-related mortality in Western countries. The assessment of histological severity in ALD now relies predominantly on non-invasive methods, particularly elastography and blood-based tests, commercially available or laboratory-developed. These non-invasiv...

Brian P. Lee, Haripriya Maddur, J. Arab et al. · 0 citations
Review Open access Oct 2026

Review Article: Fibrosis-4 Index in Steatotic Liver Disease-Past, Present and Future.

In the precision therapy era, FIB-4 remains a scalable front-door test but should not serve as a stand-alone selector for drug eligibility; confirmatory staging is required to identify F2-F3 disease and exclude cirrhosis.

K. Soni, V. Jahagirdar, Omar Albhaisi et al. · 0 citations

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