The assembly pathway for human papillomavirus L1 capsid protein is encoded in electrostatic interactions.
By carefully controlling ionic strength, and/or by mutating interface residues by design, it is possible to make high quality, highly immunogenic VLPs directly from unpurified bacterial lysate, without requiring the use of a disassembly/reassembly step.
X. Yuan, K. Nand, J. C. Patel et al.
· Protein Science · 0 citations