Abstract A062: SFRP2 Silencing Restrains Pancreatic Cancer Growth and Enhances Survival Through Remodeling of the Tumor Microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited therapeutic options. Secreted frizzled-related protein 2 (SFRP2) has emerged as an important mediator of tumor progression by promoting tumor cell survival, immune exhaustion, and angiogenesis. In human PDAC, elevated SFRP2 expressio...