Author

J. L. dos Santos

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#gene editing Review Open access Aug 2026

Epigenetic strategies for fetal hemoglobin induction in sickle cell disease.

This review discusses medicinal chemistry approaches primarily targeting HDAC1/2, LSD1, and DNMT1, with emphasis on inhibitor classes, binding mechanisms, structural features, preclinical evidence, and translational limitations, and how a better understanding of γ-globin repression may guide the development of safer an...

Mateus Mello de Souza, A. R. Pavan, Victor Gabriel de Faria Pastre et al. · European journal of medicina... · 0 citations

Review Sep 2026

Insights into the use of artificial intelligence in the drug discovery and delivery of nanosystems for the treatment of infectious diseases and neoplasms.

Artificial Intelligence (AI) has become a fundamental driver of scientific progress, particularly in disease diagnosis, drug development, and drug delivery optimization. The intersection of AI, drug design, and nanosystems for delivery is accelerating the advancement of personalized nanomedicines and innovative dianano...

Vinicius Martinho Borges Cardoso, Camila Rodrigues Santana, Giovanna Justino Momente et al. · Nanomedicine · 0 citations