Blood metabolomics capture variation in biological aging, but the circulating proteins that underlie or accompany metabolomic aging and its links to disease and mortality remain underexplored. Here, we integrated metabolomics, proteomics and genetics from UK Biobank to characterize the protein architecture of metabolom...
X. Luo, C. Liu, Y. Xie et al.· medRxiv· 0 citations
BACKGROUND Twin pregnancies have a two- to three-fold higher risk of preeclampsia (PE), but early prediction remains poor because current biomarkers and prediction models are largely derived from singleton pregnancies. Defining the biological changes that precede PE in twins may facilitate the development of more effec...
J. Li, Z. Fang, W. Tian et al.· medRxiv· 0 citations
In PsD, only IL-17i were associated with improved liver disease in addition to improving clinical PsD outcomes, and t-cell subtypes bridging innate and adaptive immunity were associated with liver disease features.
S. Gunawardana, L. James, C. Diamond et al.· medRxiv· 0 citations
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