CHAPTER 4 The HSPG binding domain of APRIL serves as a platform for ligand multimersation and cross-linking.
It is shown that the lack of HSPG interaction can be compensated by artificial cross-linking, which indicates that the HSPG-binding domain in APRIL is not necessary to allow for signalling through HSPG, but instead mediates ligand cross-linking and oligomerisation.
Fiona C. Kimberley, Liesbeth van Bostelen, Gijs Hardenberg et al.
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