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Open access Sep 2026

Validation of the General Practice Physical Activity Questionnaire after severe COVID-19

Background Physical inactivity is a risk factor for severe COVID-19 and often worsens after hospitalisation. Clinicians need quick, accurate assessments to target interventions. We aimed to assess the validity of the General Practice Physical Activity Questionnaire (GPPAQ) in adults recovering 1 year after COVID-19 hos...

Lin Wang, K. Ntotsis, J. Manifield et al. · 0 citations
#protein folding Open access Oct 2026

Frequency and Timing of Specialized Formula Prescriptions for Children Under 2 Years.

BACKGROUND Infants with non-specific symptoms are sometimes labelled as cow's milk allergic and managed with specialized formula. These products differ from standard infant formula in protein and carbohydrate source, typically containing lower quality protein and free/added sugars such as glucose polymers or sucrose. W...

N. Punjabi, Karen Li, Mark Cunningham et al. · 0 citations
Review Open access Aug 2026

Factors Associated with Uptake of Lung Cancer Screening Among High-Risk Individuals: A Systematic Review and Meta-Analysis

Low-dose computed tomography (LDCT) screening reduces lung cancer mortality through early detection. However, lung cancer screening uptake among high-risk groups remains low and varies by setting. This study aims to assess the factors associated with LDCT screening uptake among high-risk individuals. We sear...

W. Mahikul, Yifei Huang, Jiawei Yuan et al. · 0 citations
Open access Sep 2026

Prevalence and healthcare utilization of eosinophilic chronic obstructive pulmonary disease in the UK: an observational electronic health record-based cohort study

Biologic therapies offer new treatment opportunities for patients with eosinophilic COPD. However, the number and proportions of patients with COPD who would be eligible are unknown. Using data from Optimum Patient Care Research Database, we conducted a retrospective observational study of electronic healt...

C. Schnier, P. McDowell, John Busby et al. · 0 citations
Review Open access Sep 2026

Assessing the public health impact of routinely collected electronic healthcare record data in NICE guidelines: A systematic review of CPRD research.

OBJECTIVES Evidence used in NICE guidance has traditionally prioritised randomised controlled trials, but increasing availability of electronic health record (EHR) data has expanded opportunities for real-world evidence. The Clinical Practice Research Datalink (CPRD) is a commonly used UK primary care EHR resource, yet...

Alwin Paul, Ikenna Nwogu, Susan Hodgson et al. · 0 citations
Review Open access Sep 2026

Temporal trends in single and multiple organ fibrosis prevalence and primary care consultations: a population-based cohort study of 5.8 million individuals in England

Abstract Objective To understand how prevalence estimates of single and multiple organ fibrosis have changed from 2012 to 2022. Design Retrospective population-based cohort study. Setting Data from primary (Clinical Practice Research Datalink Aurum) and secondary care (Hospital Episode Statistics Admitted Patient Care)...

G. M. Massen, Gisli R. Jenkins, R. Allen et al. · 0 citations
Open access Sep 2026

Genome-wide association studies to identify shared and distinct mechanisms of fibrosis across 12 organ systems

Evidence of shared genetic associations for fibrosis across organs is found, both at individual genetic loci and genome-wide, which highlights specific genes that may contribute to fibrosis across organs and diseases, which may facilitate the development of new therapies.

Ebrima Joof, T. Hernández-Beeftink, G. Parcesepe et al. · 0 citations

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