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J. Tarning

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#protein folding Oct 2026

PBPK Model-Based Prediction of Optimal Rosuvastatin Dosing with Concomitant Ticagrelor in Elderly Patients Considering ABCG2 Genetic Variant.

Aims Rosuvastatin is commonly co-administered with ticagrelor in patients with acute coronary syndrome. Ticagrelor inhibits breast cancer resistance protein (BCRP/ABCG2), increasing rosuvastatin exposure and potentially the risk of rhabdomyolysis. This risk may be further influenced by age and the ABCG2 c.421C>A varian...

D. H. Nguyen, H. T. V. Pham, J. Ding et al. · 0 citations

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