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Author

J. Viikari

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Open access Aug 2026

Ultrasound-detected fatty liver in young adults and long-term risk of atherosclerotic cardiovascular disease: The Young Finns Study.

BACKGROUND Fatty liver is the most common chronic liver disease globally and is associated with increased cardiovascular risk. Evidence specifically addressing fatty liver and cardiovascular outcomes in young adults from European population-based cohorts remains scarce. METHODS Fatty liver was assessed by abdominal u...

O. Raitakari, K. Pahkala, S. Rovio et al. · 0 citations
Open access Aug 2026

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood factors and polygenic risk scores (PRSs). Data fro...

Rooholla Poursoleymani, Ioannis Papathanail, Lorenzo Brigato et al. · 0 citations
Open access Sep 2026

Associations of lipoprotein(a) with fasting insulin, fasting glucose, and incident type 2 diabetes: a prospective analysis from the Young Finns Study

Inverse associations between Lp(a) and fasting glucose were observed in males and higher adult Lp(a) concentrations were prospectively associated with lower risk of incident type 2 diabetes, in the prospective Young Finns Study cohort.

M. Knuuti, N. Kartiosuo, K. Pahkala et al. · 0 citations
Open access Aug 2026

Adolescent weight gain trajectories and their associations with biological aging: a genetically informed study.

Higher level of adolescent BMI partly mediated the association between higher BMI-PRS and accelerated biological aging from late adolescence to middle adulthood, indicating that high BMI in adolescence may accelerate biological aging.

Anni Pitkänen, Anna Kankaanpää, E. Raitoharju et al. · 0 citations

Meta-analysis of 49(cid:0)549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.

E. V. van Leeuwen, A. Sabo, J. Bis et al. · 0 citations
Open access Aug 2026

Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

An LE8-derived DNAm score was associated with lower cIMT across the life course and, to a lesser extent, across generations, suggesting that blood DNAm reflects cumulative cardiovascular health and vascular burden and may complement conventional cardiovascular risk assessment.

B. Mishra, E. Raitoharju, L.-P. Lyytikäinen et al. · 0 citations

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