Meta-analysis of 49(cid:0)549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

E. V. van Leeuwen A. Sabo J. Bis Jennifer E. Huffman A. Manichaikul A. Smith M. Feitosa S. Demissie Peter K. Joshi Q. Duan J. Marten J. V. van Klinken Ida Surakka I. Nolte Weihua Zhang H. Mbarek R. Li-Gao S. Trompet N. Verweij Evangelos Evangelou L. Lyytikäinen B. Tayo J. Deelen P. J. van der Most S. W. van der Laan D. Arking A. Morrison Abbas Dehghan Oscar H Franco A. Hofman F. Rivadeneira E. Sijbrands A. Uitterlinden J. Mychaleckyj A. Campbell L. Hocking S. Padmanabhan J. Brody T. Harris A. Isaacs Harry Campbell Leslie A. Lange I. Rudan I. Kolčić Pau Navarro T. Zemunik V. Salomaa The LifeLines C. Study Angad S. Kooner J. Kooner B. Lehne W. Scott Sian-Tsung Tan E. D. de Geus Y. Milaneschi H. Penninx G. Willemsen R. de Mutsert Ian Ford R. Gansevoort Marcelo P. Segura-Lepe O. Raitakari J. Viikari K. Nikus Terrence Forrester C. Mckenzie A. D. de Craen Hester M. de Ruijter G. Pasterkamp H. Snieder A. Oldehinkel P. Slagboom Richard S. Cooper M. Kähönen V. Vitart O. Polašek Caroline Hayward James G. Wilson James F. Wilson V. Gudnason Stephen S. Rich B. Psaty I. Borecki E. Boerwinkle Jerome I. Rotter L. Cupples C. V. van Duijn CMvD A. Cupples Cornelia M. van Gudnason Vilmundur James F. Wilson S. Ripatti Ko Willems Van Dijk A. M. McKenzie Hester M. de Craen De Ruijter Charge Lipids T. Olli Jorma S Raitakari Kjell Viikari Terrence Nikus C. Forrester Ian Renée de Mutsert Ron T Ford Marcelo P Gansevoort J. Segura-Lepe Yuri de Geus Brenda W J Milaneschi Eco Zemunik Kenneth M Sijbrands Oscar H Dehghan A. Franco Fernando Hofman Eric J Rivadeneira S. Most D. E. van der Laan Alanna Arking A. Morrison Leo-Pekka Bamidele O. Lyytikäinen J. Tayo Peter J Deelen van der Ruifang Stella Li-Gao Niek Trompet E. Verweij Evangelou Ida Klinken Ilja M. Surakka Weihua Nolte Hamdi Zhang Mbarek Peter K Demissie Qing Joshi Jonathan Duan J. Marten Ani van Huffman A. Manichaikul MaryKate Smith Serkalem Elisabeth M Feitosa A. van Leeuwen Joshua C Sabo Jennifer E. Bis

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TL;DR

This study illustrates that GWAS with high-scale imputation may still help to unravel the biological mechanism behind circulating lipid levels and identifies more new rare and low-frequency functional variants associated with circulating lipid levels.

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