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Author

J. W. Wynne

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#gene editing Open access Oct 2026

Functional divergence of TLR5 paralogs reveals distinct roles for TLR5M and TLR5S in salmonid Immunity.

Sensing of pathogen-associated molecular patterns (PAMPs) is a critical step in mounting effective immune responses against invading pathogens. Toll-like receptor 5 (TLR5) is central to this process through its recognition of bacterial flagellin. While the function of the canonical membrane-bound form (TLR5M) appears c...

Andrew T. Wood, Aaron J. Smith, Max Charles Vallarino et al. · 0 citations
Open access Jul 2026

RfxCas13d mediates robust cross-strain suppression of highly pathogenic avian influenza viruses

A programmable RNA-targeting antiviral platform based on RfxCas13d is developed and its activity in avian cells is evaluated, establishing RfxCas13d as a versatile RNA-guided antiviral platform and providing a foundation for cross-strain influenza control through conserved RNA targeting.

Sudip Dhakal, Aaron J. Smith, Emiliana Weiss et al. · 0 citations

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