Jacques Fantini

Metabolic Structure: A Paradigm Revisited in Light of the Fundamental Parameters of Living Systems

ABSTRACT The concept of ‘metabolic structure’, which considers metabolism as a stable, genetically encoded architecture with enzymes occupying fixed control positions, is indispensable but incomplete, and it obscures metabolism's true nature. I propose redefining metabolism as a dynamic field of emergent biochemical fl...

The Disordome Paradigm: How Intrinsic Disorder Encodes Emergent Biological Function

Classical structural biology equates function with a fixed three-dimensional fold, a view challenged by intrinsically disordered proteins (IDPs) and regions (IDRs), which populate broad conformational ensembles rather than a unique structure. This article introduces the “disordome” paradigm, extending Uversky’s “unfold...

From Meteorites to Membrane Rafts: Ganglioside-Incorporating Prebiotic Vesicles and the Emergence of Membrane Domain Organization