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Author

Jaeik Oh

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Open access Aug 2026

EZH1/2 inhibition selectively targets SMARCA4/2 co-deficient lung cancer cells by suppressing stemness and proliferation

Highlights • SMARCA4/2 co-deficient lung cancer cells share transcriptomic features with SMARCA4-UT.• The EZH1/2 inhibitor HM97662 selectively suppresses growth in SMARCA4/2-deficient cells.• HM97662 induces apoptosis and attenuates stemness marker expression selectively.• Broad PRC2 target derepression, but selective...

J. Lee, Jaeik Oh, Soyeon Kim et al. · 1 citation

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