Mixed osmolytes protect charged biomolecular and nanomaterial interfaces under salt stress, but their combined effects are often nonadditive. Here we identify interfacial solute organization as a molecular criterion that determines whether a mixture is protective or antagonistic via combining computer simulations and e...
Susmita Sarkar, Nandita Mohandas, Rayantan Sadhukhan et al.· Journal of Physical Chemistr...· 0 citations
The convergence mechanism is established as a practical design principle for molecular generative sampling, clarifying when stochastic diffusion provides robustness and when deterministic transport requires higher representational capacity.
Nagesh B. E., Jagannath Mondal· Journal of Chemical Theory a...· 0 citations
2-Deoxyribose-5-Phosphate Aldolase (DERA) is a key enzyme in the pentose phosphate pathway. Due to its C-C bond formation and stereoselective capabilities, DERA has been widely used for biocatalytic applications including the synthesis of chiral intermediates for antiviral and anticancer drugs. While protein engineerin...
S. Dutta, Ananya Nayak, Jeevani Kodru et al.· bioRxiv· 0 citations
The SIRT1 exon 2-encoded IDR is identified as a non-catalytic regulatory element that contributes to the timing of hepatic transcriptional responses during nutrient stress and impair fasting adaptation and glucose homeostasis.
Arushi Shukla, Subinoy Adhikari, Chinthapalli Balaji et al.· The FASEB Journal· 0 citations
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