Sep 2026
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation.
A. Esposito, Ibrahim Bayramoglu, Chiara Varriale et al.
· Nature · 0 citations
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Jul 2026
Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system
The cryo-electron microscopy structure of the full-length human VPS4B hexamer in six-membered helical “spiral staircase” states suggests a mechanism for substrate-dependent hexamerization and priming of VPS4 for its ESCRT-III remodeling activity.
James H. Hurley, Yu-Chao Zhang, Shuixia Tan et al.
· Research Square · 0 citations