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Author

Jaroslav Zak

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Open access Sep 2026

23 PRISM: Phase 1b of Retifanlimab and Ruxolitinib in Solid Malignancies Progressing on Prior Checkpoint Inhibition (NCT07219576)

The vision is to establish JAK inhibition as a tractable strategy for restoring checkpoint sensitivity across solid tumors, providing the foundation for a biomarker-driven randomized phase 2 trial in checkpoint-refractory disease.

Rana Mckay, L.-J. Wei, Yu-Wei Chen et al. · 0 citations
Open access Jul 2026

An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

It is shown that KRASG12D mutations in lung epithelium drive proliferation of resident, embryonically-derived alveolar macrophages, which then promote tumor cell proliferation and protection from ferroptosis, leading to tumor progression.

Jaroslav Zak, Hui Chen, Erpei Wang et al. · 0 citations

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