An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

Interleukin-9 Receptor Signaling Promotes an Immunosuppressive Tumor Immune Microenvironment in Oncogene-Driven Non-Small Cell Lung Cancer 2264775

Non-small cell lung cancer (NSCLC), particularly oncogene-driven subtypes, remains a leading cause of cancer-related mortality, underscoring the urgent need for novel immunotherapies that effectively target the tumor immune microenvironment (TIME). The interleukin-9 receptor (IL-9R) signaling pathway is understud...

IL-26-driven epigenetic remodeling promotes immune evasion in colorectal cancer

A model in which tumor-specific type 17 T cells directly reprogram cancer cell epigenetics through IL-26 is supported, reshaping the tumor immune microenvironment to promote immune evasion and immune evasion.

T cells are critical for pre-metastatic niche formation through the STAT3/IL-17 axis

It is demonstrated that CD4+ T cells accumulate in tumor-free lungs and promote tumor metastasis in mouse models, and STAT3 and IL-17 in CD4+ T cells therefore are important for pre-metastatic niche formation and metastasis.

LTBP4 deficiency induces MRC1+/CD44+ macrophages to drive cancer progression in preclinical colorectal cancer models.

This study positions LTBP4 as a key modulator of tumor progression and reveals a therapeutic strategy for LTBP4-deficient CRC.

Aging-associated regulatory B-like cells establish a lung-selective immunosuppressive niche to promote pulmonary metastasis

Stk11 loss in lung adenocarcinoma increases tumor CXCL16 and is associated with an expansion of Areg+ CXCR6+ IL-17-producing γδ T cells 2310280

Tumor Immunology: Cellular Responses and Tumor Microevironment (TIME) shows that tumor-intrinsic Stk11 loss in lung adenocarcinoma is associated with an expansion of lung gdT17 cells and supports a model in which these pro-tumor cells are recruited to the KS mouse lung via a CXCL16-CXCR6 axis.