Autonomic neurons are intrinsically hyperexcitable in a Friedreich ataxia iPSC model
Friedreich ataxia (FRDA) is an inherited multisystem disorder caused by a GAA repeat expansion in the FXN gene and consequent frataxin deficiency, causing progressive neurodegeneration and heart disease. Clinical studies have documented autonomic dysfunction in FRDA, including elevated resting heart rate, raised plasma...
Shiang Yong Lim, Jarmon Lees, H Zhang et al.
· bioRxiv (Cold Spring Harbor... · 0 citations