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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Jens Carlsson

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Open access Aug 2026

Structure-guided allosteric modulation of the delta opioid receptor

Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid analgesics with reduced adverse effects compared to c...

J. Mobbs, M. D. Nguyen, Owindeep Deo et al. · 0 citations
Open access Jul 2026

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity

This work explores structure-based strategies to identify small-molecule agonists of neurotensin (NTS) receptors, leading to the discovery of potent agonists with in vivo antinociceptive effects and to insights into the molecular basis of receptor activation.

Nicolas Panel, D. D. Vo, Harald Hübner et al. · 0 citations
Jul 2026

Peptide ligand discovery of G protein-coupled receptors

This Primer outlines experimental and computational workflows tailored to peptide–GPCR interactions, including in silico peptide mining, deorphanization strategies, library-based screening platforms, modern pathway-resolved biosensor assays, and approaches for peptide stabilization and optimization strategies to addres...

J. Hermes, Marin Matic, H. Yeung et al. · 0 citations

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