Unfolding of the disease-linked bank vole prion protein E200K in the context of PrPSc propagation
The elucidation of the atomistic structure of PrPSc has, disappointingly, not revealed the mechanism underlying prion propagation. This is because PrPSc has been shown to be a standard amyloid, and as such, it can only template a polypeptide chain that is unfolded. Therefore, while PrPSc can easily template the disorde...
Sanaz Sabzehei, Hasier Eraña, Iria Díaz-Arias et al.
· bioRxiv (Cold Spring Harbor... · 0 citations