Pathogenesis of yersiniosis comprises cell-invasive events in which the bacteria subvert the endocytic-autophagolysosomal pathway of infected host cells to create an intracellular niche for bacterial replication. To determine potential virulence factors that enable intracellular proliferation of Yersinia enterocolitica...
J. Brinkmann, Jia-Bin Huang, Patrick Blümke et al.· bioRxiv· 0 citations
It is found that the mutations induce distinct transcriptional and translational alterations: rN-Alpha drives a stealth-like infection characterized by sustained translation efficiency and specific evasion of the 2’-5’-oligoadenylate synthetase (OAS) innate immune sensor, whereas rN-Delta and rN-BA trigger a highly ele...
J. Berger, Jonas Schröder, Timothy K. Soh et al.· bioRxiv· 0 citations
These findings provide the first comprehensive molecular characterization of EVs released by MCPyV-positive MCC cells and establish a foundation for investigating the contribution of EV-mediated communication to MCC biology and tumor–microenvironment interactions.
U. Westerkamp, Patrick Blümke, Amanda Salviano-Silva et al.· bioRxiv· 0 citations
The findings reveal efflux pump-specific and strain-specific adaptations to antibiotic stress, positioning CraA as a major determinant of chloramphenicol resistance, while RND transporters such as AdeABC and AdeIJK may also be associated with broader stress adaptation processes, including redox and metal homeostasis, i...
W. Foong, Xin-Xin Xiang, Wen-Jun He et al.· mSystems· 1 citation
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