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Author

Jia-Cheng Yu

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Open access Sep 2026

Locus coeruleus-spinal noradrenergic signaling drives sleep deprivation-induced hyperalgesia via astrocytic GAT-3.

Sleep deprivation is a prevalent health problem that amplifies pain and prolongs recovery after tissue injury, yet the neural and astrocytic mechanisms underlying this relationship remain poorly defined. Here, we demonstrate that sleep deprivation activates locus coeruleus noradrenergic neurons and elevates spinal nore...

Jia-Cheng Yu, Lu Han, Mei Li et al. · 0 citations
Aug 2026

Integrated genome-wide high-throughput screening and functional validation identifies Sm proteins as essential splicing regulators for gastric cancer progression

Integrating genome-wide CRISPR-Cas9 and RNA interference proliferation screening data from human GC cell lines, the integrated approach defines the Sm proteins as essential for GC progression, highlighting the therapeutic potential of targeting this splicing pathway.

Dai-Hong Chen, Jie Wu, Yonggang Zhang et al. · 0 citations

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