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Integrated genome-wide high-throughput screening and functional validation identifies Sm proteins as essential splicing regulators for gastric cancer progression

Dai-Hong Chen Jie Wu Yonggang Zhang Yu-Bo Chen Jia-Cheng Yu Juan Ye Dan Li Li-Juan Gu Juan Li Xiao-Xing Xiong Zhi Zeng
Aug 2026 · Functional & Integrative Genomics · Vol 26 · 0 citations · 77 references
Medicine

TL;DR

Integrating genome-wide CRISPR-Cas9 and RNA interference proliferation screening data from human GC cell lines, the integrated approach defines the Sm proteins as essential for GC progression, highlighting the therapeutic potential of targeting this splicing pathway.

DOI PubMed Semantic Scholar
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