Author

Jia-Cheng Zhao

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Aug 2026

Nat10-mediated ac4C modification sustains macrophage proliferation and mitigates colitis progression via Mcm2 stabilization.

This study provides the first in vivo evidence that Nat10-mediated ac4C modification sustains macrophage proliferation and attenuates colitis progression by stabilizing Mcm2 mRNA.

Jin-Song Wang, Tao Liu, Jia-Cheng Zhao et al. · Science China Life Sciences · 0 citations

Open access Aug 2026

Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage

It is demonstrated that colonic macrophage-mediated extracellular matrix (ECM) remodeling orchestrates enteric neuronal maturation and dictates colitis progression and the m6Am machinery is illuminated as a promising therapeutic target for preventing neuronal loss in IBD patients.

Chen-Bo Ding, Jia-Cheng Zhao, Tian-Hua Zhao et al. · Cellular & Molecular Immunol... · 0 citations