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Review Open access Aug 2026

Dioscin in liver diseases: pharmacological mechanisms, translational potential and future perspectives

Dioscin (C45H72O16, DIO) is a naturally occurring steroidal saponin widely distributed in medicinal plants of the Dioscoreaceae, Liliaceae, and Fabaceae families. Given its remarkable hepatoprotective properties, DIO has attracted increasing attention in recent years. Based on literature retrieved from Web of Science,...

Jia Liu, Ru-Lan Sun, Jie Huang et al. · 0 citations
Aug 2026

SREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure

Results demonstrate that SREBF2 mitigates MI-induced HF by activating the Cav-1/PINK1/Parkin axis to promote mitophagy and inhibit ferroptosis, and identify SREBF2 as a promising therapeutic target in heart failure.

Jia Li, Jia Liu, Fan-Yan Luo et al. · 0 citations

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