TL;DR
Results demonstrate that SREBF2 mitigates MI-induced HF by activating the Cav-1/PINK1/Parkin axis to promote mitophagy and inhibit ferroptosis, and identify SREBF2 as a promising therapeutic target in heart failure.
Hypertension-induced cardiac fibrosis is a major risk factor for heart failure; although disrupted mitochondrial homeostasis has been confirmed to serve a critical role in the pathological process, its upstream regulatory factors remain incompletely understood. In the current study, RNA sequencing and bioinformatics an...
Remimazolam (RMZ) is an ultra-short-acting sedative anesthetic that provides protection against cerebral and hepatic ischemia/reperfusion injury. However, its potential cardioprotective effect in myocardial ischemia reperfusion injury (MIRI) remains to be fully elucidated. The present study investigated the hypothesis...
Cerebral ischemia-reperfusion injury (CIRI) is a leading cause of neurological disability with few effective therapeutic strategies, and ferroptosis has been proven to participate in CIRI progression while its upstream regulatory mechanisms remain poorly defined. Herein, we performed transcriptomic analysis on GSE16207...
Abstract: Background: Ferroptosis-related oxidative injury has been implicated in the progression of heart failure (HF). Rosmarinic acid (RA) has antioxidant and anti-lipid peroxidation properties, but its role in HF-associated ferroptosis-related cardiomyocyte injury remains unclear. Objectives: This study aimed to in...
Myocardial ischemia-reperfusion (I/R) injury remains a leading cause of cardiac dysfunction and mortality worldwide. Serine/arginine-Rich Protein Kinase 3 (SRPK3) is highly expressed in cardiac muscle, yet its specific pathological role in I/R injury has not been fully characterized. In this study, we utilized cardiac-...
Oxidative damage-triggered ferroptosis and apoptosis drive the progression of Parkinson's disease (PD). Forkhead box O1 (FOXO1) is a critical modulator of oxidative stress, while its role in PD remains largely unexplored. Here, the FOXO1 inhibitor AS1842856 (AS) was employed to treat the MPTP-exposed mice and MPP+-chal...
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