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Author

Jianong Luo

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Aug 2026

FGD5 regulates PGK1 ubiquitination to synergize with 2-deoxy-D-glucose in pancreatic ductal adenocarcinoma

FGD5 is identified as a metabolic vulnerability that increases PDAC sensitivity to the glycolysis inhibitor 2-deoxy-D-glucose (2-DG) and a mechanistic framework supporting combinatorial strategies that couple glycolysis inhibition with perturbation of FGD5–PGK1-associated proteostasis is provided.

Wen-Ting Song, Jia-Nong Luo, Kun Cai et al. · 0 citations

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