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Author

Jiaqi Du

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Open access Sep 2026

Compartmentalized Nanozyme Transduction Enables Regenerative Molecular Amplification for Multiplexed miRNA-Based Prostate Cancer Stratification

Circulating microRNAs (miRNAs) have emerged as promising liquid biopsy markers; however, their clinical translation is restricted by low abundance, biological heterogeneity, and the complexity of multiplex profiling. Herein, we develop a targeted cycling-mediated duplex-specific nuclease (DSN)-nanozyme signal amplifica...

Ying Ma, Xiang-Lan He, Jia-Qi Du et al. · 0 citations
Aug 2026

Programmable Allosteric DNAzyme Coupled with CRISPR/Cas12a System for Multiplexed and Sensitive Detection of Extracellular Vesicle Derived MicroRNAs

A previously unrecognized feature of CRISPR/Cas12a is identified, in which incorporation of ribonucleotides into single stranded DNA targets modulates Cas12a activation efficiency, revealing a hybrid DNA/RNA-dependent regulation of Cas12a activity.

Xiang-Lan He, Le Wang, Cong Zhang et al. · 0 citations

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