Jiabin Yin

CatESO: Differentiable Enzyme Sequence Optimization Guided by Substrate-Aware K cat Prediction

Abstract Enzymes drive biological chemistry and offer greener routes to chemicals, materials, and medicines, yet their broader use as biocatalysts is often limited by insufficient catalytic turnover. Improving turnover is hard: measured rate constants are scarce and protein sequence space is vast. Deep learning models...