Biomolecular condensates, formed through phase separation of multivalent biomolecules, are central to cellular organization and function. Here, we present a unified, physics-based intermediate-resolution framework for efficient and quantitative simulation of biomolecular phase separation at near-cellular complexity. Th...
Antibiotic-resistant tuberculosis remains a major public health challenge, and rapid diagnosis of resistant infections based on genomic markers holds promise for improving time to effective treatment. However, the vast majority of clinically observed variants in resistance-associated genes remain of uncertain significa...
Mahbuba Tasmin, Shrishti Barethiya, Yu Wang et al.· bioRxiv· 0 citations
An intermediate-resolution model for condensates of DNAs (iConDNA) that can capture key local and long-range structural features of dynamic DNAs and simulate their spontaneous phase transitions is introduced, providing a suitable tool to study DNA homotypic phase separation in biological and engineering applications.
The MspA nanopore platform demonstrated using the intrinsically disordered transactivation domain of tumor suppressor p53 (p53-TAD) showed that MspA can stably capture p53-TAD and resolve up to six distinct current states with frequent interconversions, revealing a rich conformational landscape.
David DeCoeur, Samantha A Schultz, Jian-Han Chen et al.· bioRxiv· 0 citations
These findings establish antibiotic-driven phase separation as a previously unrecognized mechanism to encode cellular signaling and identify antibiotic condensates as a distinct functional unit underlying drug tolerance.
Yuefeng Ma, Wen Yu, E. Moon et al.· bioRxiv· 0 citations
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