Author

Jian-Jun Chen

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Open access Aug 2026

Discovery of Aurora A/HDAC dual-target inhibitors: broad-spectrum in vitro antitumor activity and in vivo pharmacokinetic limitations.

Z20 is a potent Aurora A/HDAC dual-target inhibitor in vitro, while its pharmacokinetic defects limit clinical potential, which highlights the necessity of optimizing pharmacokinetic profiles for translating in vitro potency to in vivo efficacy.

Li-Rong Zhang, Xuewen Zhang, Jie Zhong et al. · RSC Medicinal Chemistry · 0 citations

#protein folding Aug 2026

Discovery and Crystallographic Study of Water-Soluble Quaternary Ammonium-Based PD-1/PD-L1 Inhibitors with Anti-Angiogenic Activity

The quaternary ammonium strategy represents an effective approach to developing water-soluble PD-1/PD-L1 inhibitors with dual immunomodulatory and antiangiogenic functions.

Jianwei Xu, Pan Yang, Xixiang Yang et al. · Journal of Medicinal Chemist... · 0 citations