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Jian-Hua Li

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Review Open access Sep 2026

Unraveling the mitochondrial–lysosomal crosstalk: a new frontier in sepsis-induced acute lung injury

Sepsis-induced acute lung injury (S-ALI) and sepsis-associated acute respiratory distress syndrome (ARDS) remain major contributors to respiratory failure and mortality in critically ill patients. Mitochondrial dysfunction and lysosomal impairment are implicated in septic organ injury, but their functional interdepende...

Yan-Yang Deng, Geng-Jia Tu, Jia-Min Ma et al. · Critical Care · 0 citations

Jul 2026

circGAB1 Activates Autophagy to Promote Sepsis-Associated Acute Kidney Injury by Interacting with ELAVL1 to Activate the HMGB3/β-catenin Signaling Pathway.

Analysis of the public GEO dataset revealed that circGAB1 was significantly upregulated in SA-AKI samples, and its high expression was also verified in SA-AKI model cells, and it exhibited a nucleocytoplasmic subcellular localization pattern.

Linlin Yue, Xiaofeng Liu, Jianhua Li et al. · Applied Biochemistry and Bio... · 0 citations

Jian-Hua Li

Unraveling the mitochondrial–lysosomal crosstalk: a new frontier in sepsis-induced acute lung injury

circGAB1 Activates Autophagy to Promote Sepsis-Associated Acute Kidney Injury by Interacting with ELAVL1 to Activate the HMGB3/β-catenin Signaling Pathway​.

circGAB1 Activates Autophagy to Promote Sepsis-Associated Acute Kidney Injury by Interacting with ELAVL1 to Activate the HMGB3/β-catenin Signaling Pathway.