circGAB1 Activates Autophagy to Promote Sepsis-Associated Acute Kidney Injury by Interacting with ELAVL1 to Activate the HMGB3/β-catenin Signaling Pathway.

Linlin Yue Xiaofeng Liu Jianhua Li Xin Liu Jiying Lai Jie Wang Chaoyu Wu Zhiyuan Zhang Qianduo Li Feng Chen

Jul 2026 · Applied Biochemistry and Biotechnology · 0 citations · 31 references

Medicine

TL;DR

Analysis of the public GEO dataset revealed that circGAB1 was significantly upregulated in SA-AKI samples, and its high expression was also verified in SA-AKI model cells, and it exhibited a nucleocytoplasmic subcellular localization pattern.

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circGAB1 Activates Autophagy to Promote Sepsis-Associated Acute Kidney Injury by Interacting with ELAVL1 to Activate the HMGB3/β-catenin Signaling Pathway​.