Author

Jiawen Hu

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#gene editing Open access Oct 2026

Hybridization-Mediated Reversible sgRNA Caging Enables Tumor-Selective Gene Editing for Potentiating Antitumor Immunity via cGAS Demethylation.

Spatiotemporal precision remains a critical challenge against the gene editing technology used for disease treatment. We herein developed a tumor cell-selective CRISPR/Cas9 gene editing system by introducing a complementary single-stranded DNA (ssDNA) containing apurinic/apyrimidinic (AP) sites (AP-ssDNA) along the tar...

Hao-Yu Zhang, Ya-Jie Li, Ye-Han Wang et al. · Angewandte Chemie · 0 citations

#gene editing Oct 2026

Hybridization‐Mediated Reversible sgRNA Caging Enables Tumor‐Selective Gene Editing for Potentiating Antitumor Immunity via cGAS Demethylation

ABSTRACT Spatiotemporal precision remains a critical challenge against the gene editing technology used for disease treatment. We herein developed a tumor cell‐selective CRISPR/Cas9 gene editing system by introducing a complementary single‐stranded DNA (ssDNA) containing apurinic/apyrimidinic (AP) sites (AP‐ssDNA) alon...

Haoyu Zhang, Yajie Li, Yehan Wang et al. · Angewandte Chemie · 0 citations