SelO functions as a tumor suppressor through AMPylating Cdk5rap3.
A role for protein AMPylation in cell signaling and cancer progression is revealed and is shown to be related to cell proliferation and TGF-β-mediated migration.
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A role for protein AMPylation in cell signaling and cancer progression is revealed and is shown to be related to cell proliferation and TGF-β-mediated migration.
Integrating genome-wide CRISPR-Cas9 and RNA interference proliferation screening data from human GC cell lines, the integrated approach defines the Sm proteins as essential for GC progression, highlighting the therapeutic potential of targeting this splicing pathway.
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