Author

Jing-Mei Cha

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Open access Jul 2026

RNF220 safeguards meiotic synapsis and male fertility by antagonizing SYCE1 ubiquitination

A homozygous mutation in RNF220 , encoding a RING-type E3 ubiquitin ligase, is associated with male infertility featuring small-headed sperm, but the precise roles and mechanisms of RNF220 in spermatogenesis remain elusive. Here, we explored the function of RNF220 in spermatogenesis using a Stra8-Cre-mediated...

Jing-Mei Cha, Huijuan Lin, Yingqian Xia et al. · Cell Death & Disease · 0 citations

Open access Jul 2026

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

ABSTRACT In the central nervous system, oligodendrocytes (OLs) generate myelin sheaths to support rapid nerve impulse conduction. OL lineage cells, especially oligodendrocyte precursor cells (OPCs), feature high metabolic activity and are exposed to severe oxidative stress, but the protective mechanisms remain poorly u...

Yuwei Li, Haijun Zhang, Jieya Zhou et al. · Advancement of science · 0 citations

#gene editing Open access Aug 2026

Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease

In vivo evidence is provided supporting a model in which DJ-1 deficiency can promote key PD-like phenotypes in tree shrews, potentially involving PSer129αSyn accumulation, nigral dopaminergic neuron loss, and motor dysfunction.

Hao Li, Leyi Mei, Jing-Mei Cha et al. · Cell Death & Disease · 0 citations