Author

Jing-Yao Ma

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Aug 2026

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery.

A dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of β cell-specific targeting ligands to enable selective gene delivery to pancreatic β cells is developed and establishes a versatile platform for RNA therapeutics and gene-editing applications in...

Di Yu, Yining Zhu, A. Roca-Rivada et al. · ACS Nano · 1 citation

Jul 2026

Stabilizing Anionic mRNA Lipid Nanoparticles by Cleavable Crosslinking of Cholesterol.

Lipid nanoparticles (LNPs) are the leading platform for mRNA delivery, with their in vivo performance governed by lipid composition and colloidal stability. While anionic helper lipids can bias LNP expression toward the spleen, weak RNA-lipid interactions during purification often induce nanoparticle rearrangement and...

Yunhe Su, Joseph Choy, Xiang Liu et al. · ACS Applied Materials and In... · 0 citations

#gene editing Open access Sep 2026

Intracranial delivery of neuron-preferential lipid nanoparticles for gene-editing activity in mouse brain

Lipid nanoparticles (LNPs) are promising non-viral vectors for central nervous system (CNS) gene therapy, but effective delivery is limited by the blood-brain barrier and cell-type specificity. Here, we combined intracranial delivery with high-throughput, cluster-based screening and machine learning to identify LNP for...

S. S. Cai, Cody Slater, Veronica E. Farag et al. · Cell Reports Physical Scienc... · 0 citations