Mechanism of TRIM32 regulation of synaptic protein expression in the development of epilepsy in a rat model.
It is suggested that TRIM32 regulates synaptic protein expression in epilepsy and that its deficiency worsens anxiety-like behavior, cognitive impairment, and synaptic loss by perturbing BDNF/TrkB/CREB signaling, thereby providing insights that may inform future therapeutic strategies targeting this signaling pathway.