Mechanism of TRIM32 regulation of synaptic protein expression in the development of epilepsy in a rat model.

Ming Chen Jingrong Pei

Jul 2026 · Journal of Neuropathology and Experimental Neurology · Vol 85, pp. 1156-1163 · 0 citations

Medicine

TL;DR

It is suggested that TRIM32 regulates synaptic protein expression in epilepsy and that its deficiency worsens anxiety-like behavior, cognitive impairment, and synaptic loss by perturbing BDNF/TrkB/CREB signaling, thereby providing insights that may inform future therapeutic strategies targeting this signaling pathway.

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