Author

Jinjin Chen

2 papers indexed here

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Jul 2026

Lipid Nanoparticle-Encapsulated mRNA-Targeting CD19 for B and Plasma Cell Depletion in Autoimmune Diseases 2308376

The findings suggest that mRNab-LNPs offer a promising alternative to current therapies, providing a safer, more efficient approach to treating autoimmune diseases by resetting the humoral immune system.

Yiming Zhou, Jinjin Chen, Chi-Peng Guo · Journal of Immunology · 0 citations

#gene editing Aug 2026

Lipopolymer Nanoparticle-Mediated In Vivo CRISPR-Cas9 Editing of Mrg15 Restores Mitochondrial Mitophagy to Alleviate Metabolic-Associated Steatohepatitis.

Metabolic-associated steatohepatitis (MASH) remains difficult to treat due to the lack of interventions capable of targeting upstream disease drivers and achieving durable disease modification. The epigenetic regulator Mrg15 has been implicated in mitochondrial dysfunction and metabolic stress in the liver, suggesting...

Zixi Zhang, Jing Liao, Tingfeng Yu et al. · Advanced Healthcare Material... · 0 citations