Jonathan Clayden

Exploring the Design Space of 3 10 -helical Bundles using Non-canonical Amino Acids

Steric constraints and favored hydrogen-bonding patterns result in peptides and proteins based on α-amino acids being largely confined to α-helical and β-strand secondary structures. Although stand-alone 310 helices can be stabilized by incorporating α,α-disubstituted amino acids such as amino-isobutyric acid (Aib, U),...