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How differences in brain cell composition help define cortical folds are uncovered and a link between microscopic cellular organization and large-scale brain networks in primates is revealed.
Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.
It is shown that TLE patients have structural changes in two brain regions, the posterior cingulate cortex and dorsolateral prefrontal cortex, linked to slower processing speed and poorer working memory, which helps explain how microscopic gene patterns may contribute to large‐scale brain changes and cognitive difficul...
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