Author

Judith A. Simcox

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Open access Oct 2026

Overexpression of endoplasmic reticulum acetyl-CoA transporter AT-1 alters neuronal metabolism, growth, and synaptic activity

Summary Acetyl-CoA is a molecule central to cellular metabolic homeostasis. As part of the secretory pathway, acetyl-CoA is imported into the endoplasmic reticulum (ER) by a membrane-bound transporter AT-1 (SLC33A1). AT-1 mutations have been linked to peripheral neuropathy, developmental delay with premature death, and...

Eric R. McGregor, C. McGill, N. Arp et al. · iScience · 0 citations

Open access Sep 2026

From silos to synergy: the interdisciplinary discovery potential in redefining polyendocrine metabolic ovarian syndrome

Polyendocrine metabolic ovarian syndrome (PMOS) affects one of every eight women worldwide and is associated with high rates of cardiovascular disease, type 2 diabetes, and infertility. Polycystic ovarian syndrome (PCOS), another term for this condition, reflects a historical focus on its effects on the female reproduc...

Michaela M. Morhaus, Lauren W. Yowelunh McLester-Davis, Judith A. Simcox · Journal of Clinical Investig... · 0 citations

RISING STAR ABSTRACTS Beyond Ensemble Measurements: Resolving Antigen Binding and Conformational Heterogeneity in Multispecific Antibodies

These findings reveal that the RSV F antigen recognizes both the wild-type and AAS-mutated bispecific antibodies in a conformation-dependent manner, with binding preferentially observed for larger conformations.

Fanny C. Liu, Thais Pedrete, Andrew H. Beaven et al. · 0 citations