Author

Julia A. Horsfield

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#protein folding Open access Sep 2026

Hierarchical cysteine oxidation controls reversible amyloid formation in an ankyrin repeat protein

It is shown that a zebrafish protein, drP18, can transition into an amyloid fold, driven by a sophisticated two-cysteine oxidation mechanism, suggesting that oxidation-driven amyloid formation can act as a more general mechanism of protein regulation.

A. Sethi, Hannah Darroch, N. J. Magon et al. · bioRxiv · 0 citations

Open access Aug 2026

Loss of cohesin subunit Stag1 in zebrafish limits cell cycle progression and is compensated by altered BMP signalling and metabolic pathways

It is shown that, unlike mammals, zebrafish can tolerate complete loss of Stag1 from embryogenesis through to adulthood, and it is proposed that modulation of growth and signalling pathways compensates for the absence of Stag1, allowing embryonic development to proceed correctly.

Dylan M. Lynch, Anastasia A. Labudina, Sarada Ketharnathan et al. · bioRxiv · 0 citations